Approved on: | 2024-10-11 |
Brief purpose of the study: | The research study is to investigate whether increased plasma endosomal EnNaC is positively correlated with arterial stiffening in obese or hypertensive individuals. |
Brief summary of what participants will be asked to do: | We will collect 25 ml venous blood through venous venipuncture and measure blood pressure in all participants. Meanwhile, all participants’ vascular function will be examined by non-invasive SphygmoCor XCEL System. The SphygmoCor XCEL System is a tool used to check how healthy blood vessels are. It works by measuring the speed at which blood pressure waves move from the carotid artery in the neck to the femoral artery in the thigh. To do this, it uses a small sensor placed on the neck and cuffs on the thigh. The system inflates the cuffs to capture blood pressure wave patterns. By analyzing how fast these waves travel, it helps us understand how stiff or flexible arteries are. This is a non-invasive minimal risk procedure. |
Basic eligibility criteria: | Participants aged between 18-35 years at the time of enrollment will be recruited. Healthy volunteers are individuals without hypertension, obesity, diabetes, heart disease, renal disease and medications.
Clinical hypertension is diagnosed when systolic blood pressure is ≥130 mmHg and/or diastolic blood pressure is ≥ 80 mmHg. Obesity is diagnosed as a body mass index (BMI) > 30. Participants with hypertension on medication, or obesity with or without diabetes on medication, are eligible for recruitment. |
Study contact for more information: | Guanghong Jia, PhD
(573) 882-8805
jiag@health.missouri.edu |
IRB Number: | 2099320 MU |