| Approved on: | 2026-03-11 |
| Brief purpose of the study: | The purpose of this study is to examine the effects of grape consumption on immune and gut health. Further, we will explore the interrelationship of these outcomes with body composition, metabolic markers, lifestyle, environmental, perceived stress, and cognitive and mental health outcomes. |
| Brief summary of what participants will be asked to do: | Study design:
• 1-hour and 15-minute screening visit at MU
• Four 2-hour and two 45-minute study visits at MU
• Study foods provided: whole freeze-dried grape powder or placebo powder to be mixed with water and consumed like a shake
Total compensation: $250
Individual study measurements
• Blood collections for immunity and metabolic assessments
• Stool collection for microbiome and gut health markers
• Weight, body composition, bone health
• Cardiovascular tests
• Diet and sleep records
• Appetite and palatability ratings
• Physical activity with research-grade trackers
• Attention and memory tests
• Mental well-being and stress surveys
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| Basic eligibility criteria: | Inclusion criteria include:
• Age: 30-45 years
• Weight status: obese (BMI: 30-45 kg/m2)
• Willingness to consume study foods
• Consistent diet and activity patterns for 4 weeks
• Weight stable (≤5 kg change over last 3 months)
• Not currently consuming an extremely healthy diet
• Non-smoker >1 year or more
• No allergies to study foods
• Not pregnant or lactating
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| Study contact for more information: | Caitlyn Winn: nepimmunehealthstudy@missouri.edu |
| IRB Number: | 2128808 MU |
