| Approved on: | 2026-04-06 |
| Brief purpose of the study: | The purpose of this study is to evaluate the relationship between metrics of blood brain flow in comparison to motor function performance. This study serves as a pilot study of healthy subjects and will be used as the foundation for studying blood brain flow and motor function performance in concussion recovery. |
| Brief summary of what participants will be asked to do: | Participants will arrive fasted to their testing block, which includes completing an initial screening form, followed by indices of cerebral blood flow using transcranial doppler ultrasound (TCD), a non-invasive method of assessing cerebral blood flow velocity, and motor function measurements. The visual protocol will consist of a period of eyes closed (~2min) followed by 5 trials of 40 seconds of eyes opened while performing a visual task (Where’s Waldo) followed by eyes closed for 30 seconds. Following the visual task and a period of quiet rest, cerebrovascular reactivity (CVR) will be assessed during two 20 second end-expiratory apneas, each followed by a 2-min washout to ensure hemodynamics variables return to baseline. Participants will complete a battery of motor function tests that include tasks such as walking, stepping down, balancing in different conditions, and jumping testing will add cognitive tasks to motor tasks to assess dual tasking. Data will be collected through the MPASS’s force plate and depth camera for analysis. |
| Basic eligibility criteria: | To be eligible for this study, subjects must be healthy with no diagnosed chronic conditions, non-smoker or nicotine users, 18-45 years old, with a BMI greater than and/or equal to 18 kg/m2 |
| Study contact for more information: | Elena Doctor emd7m9@umsystem.edu
716-803-0705 |
| IRB Number: | 2129338 MU |
