Research studies seeking participants

Estrogen receptor alpha signaling in endothelial cells exacerbates arterial stiffening via upregulation of ENaC in insulin resistant females
Approved on:2024-01-24
Brief purpose of the study:In this study, we want to find out more about a drug, called amiloride, for people with risks factors for blood vessel stiffness. We want to find out if amiloride reduces blood vessel stiffness.
Brief summary of what participants will be asked to do:There will be 9 study visits including some in-person visits and some phone call visits (over 6 months). You will have vital signs, blood draws, DEXA scans, vascular measurements, questionnaires and oral glucose tolerance tests completed during this study. Compensation is provided.
Basic eligibility criteria:Adults, ages 30-70 Participants must be overweight, and must NOT use tobacco products. Participants can NOT be diabetic.
Study contact for more information:Andrea Atkins email- wiesa@umsystem.edu phone- (573) 882-8591
IRB Number:2012990 MU
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